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KMID : 1094719990040040277
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Biotechnology and Bioprocess Engineering
1999 Volume.4 No. 4 p.277 ~ p.280
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Effect of sugar concentration on camptothecin production in cell suspension cultures of Camptotheca acuminata
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Kim Sung-Hye
Hur Byung-Ki
Byun Sang-Yo
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Abstract
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Studies for the effects of sugar concentration on camptothecin production in suspension cultures ofCamptotheca acuminata were made with different concentrations of sucrose, glucose, and fructose. Sucrose among tested carbon sources increased the camptothecin production. The highest camptothecin, 29×104 mg/L, was obtained at 6% of sucrose that was 11 times higher than that at 2% of sucrose. Kinetics of camptothecin production with 6% of sucrose showed the camptothecin production was increased up to 3 days and then decreased after 6 days from inoculation. The highest camptothecin was obtained on the third day from inoculation.
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KEYWORD
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camptothecin, Camptotheca acuminata, sucrose effect
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